What are exosomes?
Exosomes are tiny, natural vesicles that facilitate cell-to-cell communication. They carry proteins, RNA, growth factors, and cytokines to support tissue repair. In skincare, they stimulate cellular renewal and skin rejuvenation. Exosome-infused products promote a youthful, glowing complexion with long-lasting results. They harness cutting-edge biotechnology for deep skin revitalization
What can Exosomes do?
Exosomes are transforming regenerative medicine and skincare by offering a powerful, cell-free alternative for tissue repair and rejuvenation. They accelerate healing through immune modulation (reducing inflammation), angiogenesis stimulation (promoting new blood vessels), and cellular regeneration (delivering growth factors and bioactive molecules). This cutting-edge technology harnesses the skin’s natural repair mechanisms, providing deep renewal, lasting radiance, and age-defying results.
Why use noblesse® exosomes?
We go beyond temporary solutions to deliver a scientifically proven, transformative approach to ageless skin. Our cutting-edge exosome technology works at the deepest levels of your skin, targeting the root causes of aging to stimulate true cellular renewal. It’s a holistic, long-term solution for visibly radiant, youthful skin that stands the test of time. With our innovative formulations, you’re not just investing in skincare; you’re embracing a future of lasting beauty and confidence
Proven Efficacy & Consistency
Our exosomes are derived from a stable immortalized stem cell line, ensuring batch-to-batch consistency and guaranteed results, unlike traditional stem cell-based solutions.
High Cellular Activity Rate
Our exosomes contain a potent concentration of growth factors, cytokines, and bioactive molecules, promoting rapid cellular repair and renewal for visibly youthful skin.
Backed by Global Experts
Developed in collaboration with leading researchers and scientists, our technology is at the forefront of regenerative skincare innovation, bringing cutting-edge biotech to beauty.
Exosomes and its uses
Exosome in Skincare
Exosomes are transforming skincare by delivering bioactive molecules like growth factors and cytokines to stimulate collagen production, enhance cellular repair, and improve skin elasticity for a more youthful, radiant complexion. They reduce fine lines, wrinkles, and inflammation while strengthening the skin barrier for better hydration and protection. With their ability to modulate immune responses and target specific skin concerns—such as acne, rosacea, and pigmentation—exosome-based treatments offer clinically proven, science-backed rejuvenation, promoting faster healing, improved texture, and long-term skin health.
Exosome in Haircare
Exosomes are revolutionizing haircare by harnessing their natural regenerative abilities to repair and rejuvenate hair. These microscopic messengers deliver growth-stimulating proteins and nutrients directly to hair follicles, promoting thicker, stronger hair growth while reducing inflammation and scalp irritation. Ideal for addressing thinning hair, damage, and slow growth, exosomes strengthen follicles, enhance shine, and improve overall hair health—offering a cutting-edge, science-backed solution for lasting results.
Selected Research Papers
2023
A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, “Therapeutic advances with native and engineered human extracellular vesicles” (Toh, W. S., Yarani, R., El Andaloussi, S., Cho, B. S., Choi, C., Corteling, R., De Fougerolles, A., Gimona, M., Herz, J., Khoury, M., Robbins, P. D., Williams, D., Weiss, D. J., Rohde, E., Giebel, B., & Lim, S. K.) (2023). Cytotherapy, 25(8), 810–814
2022
Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement (Salomon, C., Das, S., Erdbrügger, U., Kalluri, R., Kiang Lim, S., Olefsky, J. M., Rice, G. E., Sahoo, S., Andy Tao, W., Vader, P., Wang, Q., & Weaver, A. M.) (2022). Endocrine reviews, 43(3), 441–468.
2021
Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV) (Tan, T. T., Lai, R. C., Padmanabhan, J., Sim, W. K., Choo, A. B. H., & Lim, S. K.) (2021). Pharmaceuticals (Basel, Switzerland), 14(4), 345.
Practical considerations in transforming MSC therapy for neurological diseases from cell to EV (Tan, T. T., Toh, W. S., Lai, R. C., & Lim, S. K.) (2022). Experimental neurology, 349, 113953.
Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles (Gimona, M., Brizzi, M. F., Choo, A. B. H., Dominici, M., Davidson, S. M., Grillari, J., Hermann, D. M., Hill, A. F., de Kleijn, D., Lai, R. C., Lai, C. P., Lim, R., Monguió-Tortajada, M., Muraca, M., Ochiya, T., Ortiz, L. A., Toh, W. S., Yi, Y. W., Witwer, K. W., Giebel, B., … Lim, S. K.) (2021). Cytotherapy, 23(5), 373–380.
2018
Topical Application of Yolk Lecithin Liposomes Reinforces Skin Barrier Function Against Chemical Agents Such as Psoriasis-inducing IMQ and Alleviates Disease Phenotype. Clinical & Experimental Dermatology and Therapies.Lai, R. C., Yeo, R. W. Y., Zhang, B., Koh, M. J. A., Tan, S. S., Sim, W. K., Ang, S. B., Foong, Y. W. A., Ng, M. J., Tan, K. H., & Lim, S. K. (2018).
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. Pickart L, Margolina A. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987. PMID: 29986520; PMCID: PMC6073405.
2015
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. Pickart L, Vasquez-Soltero JM, Margolina A. 2015;2015:648108. doi: 10.1155/2015/648108. Epub 2015 Jul 7. PMID: 26236730; PMCID: PMC4508379.
2010
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem cell research, 4(3), 214–222. Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., Pasterkamp, G., de Kleijn, D. P., & Lim, S. K. (2010).
2008
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. Stem cell research, 1(2), 129–137. Timmers, L., Lim, S. K., Arslan, F., Armstrong, J. S., Hoefer, I. E., Doevendans, P. A., Piek, J. J., El Oakley, R. M., Choo, A., Lee, C. N., Pasterkamp, G., & de Kleijn, D. P. (2007).